I am a postdoctoral researcher in Prof. Sir David Klenerman's lab at the Yusuf Hamied
Department of Chemistry, University of Cambridge, UK. I hold a PhD in Neuroscience
(gold medal) from the Indian Institute of Science (IISc), Bangalore, India. My research
focuses on understanding nanoscale triggers of neurodegenerative disorders, such as
Alzheimer’s disease, through biophysical approaches, particularly how changes at
intact and extracted synapses (synaptosomes) contribute to disease onset. This was
piqued during my PhD research (Kedia et al., 2020; Kedia et al., 2021) and continues
to evolve within my current research at Cambridge, where I am attempting to address
the challenges associated with super-resolution imaging of synapses, synaptosomes,
and pathological aggregates from mice, human brain tissues, and iPSC-derived
neurons.
Selected Publications:
Kedia, S., Mandal, K., Netrakanti, P. R., Jose, M., Sisodia, S. S., & Nair, D. (2021).
Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase
complex, as independent molecular domains. Molecular brain, 14(1), 158.
Kedia, S., Ramakrishna, P., Netrakanti, P. R., Singh, N., Sisodia, S. S., Jose, M.,
Kumar, S., Mahadevan, A., Ramanan, N., Nadkarni, S., & Nair, D. (2020). Alteration in
synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's
disease. iScience, 24(1), 101924.
Kedia, S., Ramakrishna, P., , Netrakanti, P. R., , Jose, M., , Sibarita, J. B., , Nadkarni,
S., , & Nair, D., (2020). Real-time nanoscale organization of amyloid precursor
protein. Nanoscale, 12(15), 8200–8215.
Photo: Adam Smith