Yunzhao (Trevor) Wu did his Ph.D. in Prof. Sir David Klenerman's group, focusing on the characterisation and detection of p53 aggregates. During his Ph.D. and post-doc, he developed an ultrasensitive immunoassay for detecting p53 aggregates in cancer patients' plasma and demonstrated its potential in the early diagnosis of several types of cancer. He also works to develop high-throughput imaging systems, such as a cost-efficient super-resolution microscope, to characterise protein aggregate structures and support biomarker validation.
Selected Publications:
Wu Y, Lam JYL, Pitoulias M, et al. Detection of p53 aggregates in plasma of glioma patients. Comms Med 2025;5.
Böken D, Wu Y, Zhang Z, Klenerman D. Detecting the undetectable: Advances in methods for identifying small tau aggregates in neurodegenerative diseases. Chembiochem 2025;26.
Xia Z*, Wu Y*, Lam JYL, et al. A computational suite for the structural and functional characterization of amyloid aggregates. Cell Rep Methods 2023;3.
Julian L, Sang JC, Wu Y, et al. Characterization of full-length p53 aggregates and their kinetics of formation. Biophys J 2022;121.
Danial JSH*, Lam JYL*, Wu Y*, et al. Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging. Nat Protoc 2022;17.