David Sedley's books include The Hellenistic Philosophers (1987, with A.A. Long), Lucretius and the Transformation of Greek Wisdom (1998), Plato's Cratylus (2003), The Midwife of Platonism: Text and Subtext in Plato's Theaetetus (2004), and Creationism and its Critics in Antiquity (2007, from his 2004 Sather Lectures at the University of California, Berkeley).

He works on the editing of philosophical papyri, and has also been editor of Classical Quarterly (1986-1992) and Oxford Studies in Ancient Philosophy (1998-2007).

David Sedley's Lady Margaret Lecture on Socrates vs Darwin.